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Post­doc­to­ral scien­tist/PhD stu­dent (f/m/x)

ID: 206482

Art des Jobs Vollzeit
Eingetragen am 15.09.2021
Einsatzort Dresden

Jobbeschreibung These full time positions are initially for 36 months with a possibility for extension.

A postdoctoral position and a PhD student position are immediately availablein the area of genome stability in the mammalian germlinein the lab ofAttila Toth. The Toth lab is at theTechnische Universität Dresden, which is one the few Elite Universities in Germany, featuring a life sciences focus area, and a highly international and collaborative research community.The Toth group strives to uncover the molecular mechanisms of chromosome biology that ensure safe transmission of genetic information to the germline. Generation of haploid gametes from diploid germ cells by meiosis is the hallmark of sexually-reproducing organisms. Orderly halving of chromosome numbers poses unique challenges which require meiosis-specific features of chromosome biology.

One of the key features of meiosis is a modified homologous recombination that initiates with the generation of potentially genotoxic DNA breaks. Careful regulation of meiotic recombination initiation is pivotal for the generation of gametes with healthy genomes, yet, the understanding of the underlying mechanisms is sketchy. This ambitious project will explore the principles that control spatiotemporal dynamics of meiotic recombination initiation in mice. We will combine advanced chromatin analysis, cytology and large scale sequencing technologies. Further, the project involves a close cooperation with physicists/bioinformaticians in the campus to develop quantitative models for recombination. Relevant articles of the lab, doi:10.1093/nar/gkab082. doi: 10.1016/j.molcel.2019.03.022. doi: 10.1038/ncb3417. doi: 10.1038/ncb2213
Qualifikationen Your Profile:
- We are seeking scientists with experience in molecular and cellular biology. Skills in chromosome and genome biology, e.g. ChIP-seq, CUT&RUN, ATAC-seq or similar are advantageous.
Firma Medizinische Fakultät Carl Gustav Carus Dresden
01307 Dresden
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